DRUG PROFILE Sevelamer hydrochloride: a calcium- and metal-free phosphate binder
نویسندگان
چکیده
10.1586/14750708.2.6.823 © 2 Sevelamer hydrochloride is a nonabsorbed, calciumand metal-free phosphate binder, used to bind phosphate and prevent phosphate accumulation in patients with kidney failure. Sevelamer hydrochloride has been an important alternative to calcium-based phosphate binders, because calcium-based binders result in increased gastrointestinal calcium absorption and a positive calcium burden in dialysis patients. Recent studies have shown that sevelamer hydrochloride slows the progression of cardiovascular calcification when compared with calcium-based binders – such decreases in cardiovascular calcification may potentially lead to a reduction in morbidity and mortality in dialysis patients.
منابع مشابه
Treatment of hyperphosphatemia with sevelamer hydrochloride in hemodialysis patients: a comparison with calcium acetate.
BACKGROUND Sevelamer hydrochloride is a recently approved calcium- and aluminium-free phosphate binder. A randomized study comparing sevelamer and calcium acetate was performed to assess the control of hyperphosphatemia in hemodialysis patients. METHODS Administration of phosphate binders was discontinued during a two-week washout period. The patients were then randomized to receive sevelamer...
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Hyperphosphatemia is an inevitable consequence of end stage chronic kidney disease and is present in the majority of dialysis patients. Recent observational data has associated hyperphosphatemia with increased cardiovascular mortality among dialysis patients. Dietary restriction of phosphate and current dialysis prescription practices are not enough to maintain serum phosphate levels within the...
متن کاملSevelamer carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on hemodialysis
Sevelamer carbonate is an anion exchange pharmaceutical, developed to improve on the performance of the non-absorbable, non-calcium, and metal-free phosphate binder sevelamer hydrochloride. Sevelamer carbonate is expected not to worsen metabolic acidosis, as previously reported during long-term treatment with sevelamer hydrochloride in hemodialysis (HD) patients. Carbonate is the alternate coun...
متن کاملEvaluation of calcium acetate/magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: a controlled randomized study (CALMAG study) assessing efficacy and tolerability
BACKGROUND Phosphate binders are required to control serum phosphorus in dialysis patients. A phosphate binder combining calcium and magnesium offers an interesting therapeutic option. METHODS This controlled randomized, investigator-masked, multicentre trial investigated the effect of calcium acetate/magnesium carbonate (CaMg) on serum phosphorus levels compared with sevelamer hydrochloride ...
متن کاملImproving phosphate-binder therapy as a way forward.
Aluminium- or calcium-based phosphate-binding agents traditionally have been used to treat hyperphosphataemia in patients with end-stage renal disease. Although these agents effectively lower serum phosphorus levels, they are associated with serious side effects. Aluminium-based agents are associated with bone toxicity, renal osteodystrophy and encephalopathy, and calcium-based agents increase ...
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